Provera (medroxyprogesterone) is a form of the female hormone progesterone used to treat secondary amenorrhea; abnormal bleeding from the uterus due to hormonal imbalance and not due to fibroids, or cancer; and to prevent endometrial hyperplasia in postmenopausal women who have not undergone a hysterectomy and are receiving conjugated estrogens. Provera is used for contraception and for treating endometrial or renal cancer. A generic version of Provera is available. Side effects of Provera include:
breast tenderness or discharge,
loss of scalp hair,
spotting or break-through bleeding,
changes in menstrual periods,
vaginal itching or discharge,
changes in appetite,
increased or decreased weight,
sleep problems (insomnia), and
jaundice (yellowing of the skin or eyes), or
skin color changes.
Provera may increase risk of heart attacks, stroke, breast cancer, blood clots, and pulmonary emboli in postmenopausal women.
The dose of Provera varies depending on the indication. Provera inhibits fertility at high doses. Provera may interact with other drugs. Tell your doctor all medications and supplements you use. Avoid smokingwhile taking Provera due to a greatly increased risk of blood clots. Provera passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.
Our Provera Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The following adverse reactions have been reported in women taking PROVERA tablets, without concomitant estrogens treatment:
Abnormal uterine bleeding (irregular, increase, decrease), change in menstrual flow, breakthrough bleeding, spotting, amenorrhea, changes in cervical erosion and cervical secretions.
Breast tenderness, mastodynia or galactorrhea has been reported.
Thromboembolic disorders including thrombophlebitis and pulmonary embolism have been reported.
Nausea, cholestatic jaundice.
Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. Acne, Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. Acne, alopecia and hirsutism have been reported.
Neuro-ocular lesions, for example, retinal thrombosis, and optic neuritis.
Central Nervous System
Mental depression, insomnia, somnolence, dizziness, headache, nervousness.